Antigenicity and immunogenicity of collagen.

نویسندگان

  • A K Lynn
  • I V Yannas
  • W Bonfield
چکیده

Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief discussion of the fundamental concepts of collagen immunochemistry is presented, with a subsequent review of documented clinical responses to devices containing reconstituted soluble or solubilized collagen. The significance of atelocollagen, concerns regarding collagen-induced autoimmunity, and other relevant topics are also addressed in the context of current understanding of the human immune response to collagen.

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عنوان ژورنال:
  • Journal of biomedical materials research. Part B, Applied biomaterials

دوره 71 2  شماره 

صفحات  -

تاریخ انتشار 2004